1 (860) 337 2010 info@EOSM.NET

The Center for Regenerative Medicine at Eastern Orthopaedics and Sports Medicine

Platelet Rich Plasma And Stem Cell Treatments

Note: These are areas where our knowledge continues to grow as we learn more about the amazing potential for the body to heal itself. Dr.Alleyne has studied regenerative science since medical school and a research fellowship at Harvard/MIT HST under the direction of National Medal of Science winner Cato Laurencin MD, PhD. We strongly believe in the role of biologic healing as part of the treatment of our patients alongside medication, homeopathic treatments, physical therapy and when necessary surgical interventions. The information below is meant to educate and offer another treatment option for patients but is not a guarantee or presentation of a “cure all” or a “guaranteed way” to avoid other treatments including surgery. – Kenneth R Alleyne MD

Stem Cell Therapy is a non-surgical injection treatment utilizing a patient’s own powerful cells to accelerate healing. The human body is made of billions of specialized cells that form specific organs like the brain, skin, muscles, tendons, ligaments, joints, cartilage and bone.. Each day these cells go through a degenerative (break down) and regenerative (growth) process. As older cells die, new cells are born from stem cells with the unique capability of being able to create multiple types of other cells. However, when tissues are injured, the degenerative (break down)  process exceeds this regenerative (growth) process, resulting in structures that become weaker, painful and less functional. While there are several types of stem cells, those that are best at promoting musculoskeletal healing (tendon, ligament, cartilage and bone) are found in adipose tissue (fat) and bone marrow. These mesenchymal stem cells, or MSCs, are essential to successful patient outcomes and at Eastern Orthopedics and Sports Medicine  we utilize patented processes and protocols to insure the best outcome for patients undergoing stem cell treatments. Stem cell treatments are carried out in the office and are used to treat:

1.Osteoarthritis

2.Tendon damage, injury or Chronic Inflammation (Tendonitis or Tendon Tears of the Shoulder, Knee and Elbow)

FAQ: Stem Cells

What is adipose tissue?

Adipose tissue, or fat, is a medical term for loose connective tissue composed of adipocytes (cells that store fat). Its main role is to store energy, although it also cushions and insulates the body.

What is the concentrated tissue?

Concentrated adipose tissue is created when fat is removed (aspirated) from your own body and spun in a centrifuge to remove waste and create a graft rich in mesenchymal stem cells (MSCs). This autologous (meaning “from your own body”) graft is ready to be injected into the application site.

What are the benefits of adipose and concentrated adipose tissue?

Adipose tissue contains a significant concentration of MSCs and is used as an MSC-rich scaffold that may aid in tissue regeneration.45,46

Because the tissue comes from your own body, using concentrated adipose tissue reduces the risk of infection or immune reaction that can be associated with other products.

What is concentrated adipose tissue used to treat?

There is a wide range of treatment applications for concentrated adipose tissue, including:

  • Plastic and reconstructive surgery
  • Arthroscopic surgery
  • Orthopedic surgery
  • Gastrointestinal surgery
  • General surgery
  • Gynecological surgery
  • Laparoscopic surgery
  • Neurosurgery
  • Thoracic surgery
  • Urological surgery

How is it used at Eastern Orthoopaedics?

At Eastern Orthopedics Center for Regenerative Medicine stem cells are used to augment the body’s ability to heal. With this in mind, in the office stem cells are used to attempt to improve the likelihood of healing damaged tendons, ligaments and cartilage. There are times when the tissues are too far damaged to have reliable healing.

What is the procedure?

The collection of adipose tissue is a minimally invasive procedure is performed in the office using local anesthetic lick lidocaine. However, if concentrated adipose tissue is to be used as part of a surgical treatment, the adipose tissue will be collected and prepared at the time of your surgery.

Adipose tissue collection and preparation includes several key steps:

  • Your clinician begins by cleaning, draping and anesthetizing the area where the adipose tissue will be drawn from—usually the lower abdomen.
  • After the area is numb, a syringe is used to gently aspirate a small volume of fat tissue. Most commonly, 20 mL to 60 mL is needed.
  • The adipose tissue from the syringe is placed into a medical device designed to concentrate the collection while you wait.
  • The area of your body where the concentrated adipose tissue is needed is anesthetized, and the concentrated adipose tissue is delivered. 

Unless you are undergoing surgery, this is generally an outpatient procedure.

Is the use of concentrated adipose tissue safe?

The use of concentrated adipose tissue is a safe, clinically accepted procedure.

Please consult your insurance company to verify coverage. Every payer has different guidelines for reimbursement, but generally PRP procedures are not reimbursed. There is reimbursement for some of the expenses associated with concentrated bone marrow and concentrated adipose tissue procedures, but the physician or hospital must follow applicable coding and reimbursement guidelines from the payer. This means that some or all of the costs associated with the procedures using these autografts may need to be covered by the patient at the time of treatment.

For More Information Please Review the Stem Cell Page at the American Academy of Orthopedic Surgeons Web Site Here: American Academy of Orthopedics Article on Stem Cells for Patients

Platelet-Rich Plasma (PRP)

For More Information on PRP please visit the American Academy of Orthopedic Surgeons Web Site Here:

American Academy of Ortrhopedics Article on PRP for Patients

Platelet Rich Plasma Therapy (known as PRP) is also a non-surgical injection treatment. It differs from stem cells in that it uses the healing factors found in blood plasma to heal degenerative or acute damage in joints.

Platelet Rich Plasma (PRP) contains healing growth components from your own blood that increase your body’s natural ability to repair itself. The use of PRP to repair joint, tendon, ligament, and muscle injuries is becoming well known, thanks to exposure from professional athletes. Platelet injection treatments are effective because they have a stimulating effect on the stem cells within the targeted area, making those stem cells work harder to heal damaged tissues. PRP treatments differ from Stem Cells in that the active component are healing proteins and factors in your blood and not cells.

 

Our Advanced Platelet Procedures are more pure and concentrated than those created by the automated machines used at most regenerative medicine clinics. Platelet procedures are commonly used for soft tissue injuries, mild arthritis and spine condition

Platelet Rich Plasma FAQ:

What are platelets?

Platelets are small, colorless, disk-shaped cell fragments lacking a nucleus that are found in blood and play an imperative role in clot formation. They also have antimicrobial properties that support healing, infection control and the release of growth factors. These growth factors orchestrate the key biological processes required for healing.

What is PRP?

Plasma is a fluid component of blood that contains water, vital proteins, salts, minerals, sugars, fats, hormones and vitamins. PRP is plasma with a higher concentration of platelets than is generally found in blood.

What are growth factors?

Growth factors are necessary to initiate tissue repair at a wound site. Growth factors derived from platelets are responsible for soft tissue repair, bone regeneration, development of new blood vessels and stimulation of the wound healing process.13,17,18  The concentrated platelets in PRP may help optimize the conditions for healing.11,14

Is PRP safe?

The use of PRP is a safe, clinically accepted procedure. 

Is the procedure covered by insurance?

Please consult your insurance company to verify coverage. Every payer has different guidelines for reimbursement, but generally PRP procedures are not reimbursed. There is reimbursement for some of the expenses associated with concentrated bone marrow  and concentrated adipose tissue procedures, but the physician or hospital must follow applicable coding and reimbursement guidelines from the payer. This means that some or all of the costs associated with the procedures using these autografts may need to be covered by the patient at the time of treatment.

Is the procedure covered by insurance?

Please consult your insurance company to verify coverage. Every payer has different guidelines for reimbursement, but generally PRP procedures are not reimbursed. There is reimbursement for some of the expenses associated with concentrated bone marrow  and concentrated adipose tissue procedures, but the physician or hospital must follow applicable coding and reimbursement guidelines from the payer. This means that some or all of the costs associated with the procedures using these autografts may need to be covered by the patient at the time of treatment.

One of the most frequent questions we answer is how do we decide when to use Platelet Rich Plasma Therapy and when do we use Stem Cell Therapy to treat osteoarthritis and joint degeneration? Secondly, “Why not use stem cells and PRP on every patient?”

It is in the best interest of the patient to use simple treatments if simple treatments will do the job of achieving the patient’s goal of healing. Our treatments are individualized to the patient and what we feel will provide the best outcome and value for the expenditure of healthcare dollars.

Combining Stems Cells With Platelet Rich Plasma Therapy

Combining stems cells with Platelet Rich Plasma Therapy as a means to accelerate tissue regeneration in advanced degeneration has been the subject of numerous animal and human studies.

The combination provides a safe but comprehensive opportunity for healing particulary in patients who are aggressively hoping to avoid or delay surgery. This decision is made in consultation with Dr. Alleyne. There is research to suggest that stem cells have an ability repair cartilage and bone damage. They can differentiate or change themselves into the raw material to rebuild bone and soft tissue. When injected into a damaged area they signal the native healing and inflammatory cells in the joint and jump start the immune system’s rebuilding process. These signals are received by the blood plasma cells and confirmation signals are sent back. This starts the healing cascade. Sometimes in an injury depleted joint more plasma cells are needed to fix or rebuild the communication network and to provide growth and healing factors.

All the healing elements in the body to travel through the blood, so using blood as a delivery vehicle makes sense.

Platelet Rich Plasma has the ability to both increase stem cells and guide them in healing. In initial findings, PRP assisted stem cells in “figuring out” what they needed to be – whether a cartilage cell, or a bone cell, or a collagen cell for ligaments and tendons.

So the platelets are already attuned to provide a healing environment or “scaffold” to build on. In the research cited below results confirmed that PRP enhances MSC stem cell proliferation and suggested that PRP causes chondrogenic differentiation of MSC in vitro – in other words, the platelets told the stem cells what to do.

The platelets themselves secrete a variety of cytokines (proteins that regulate various inflammatory responses), including adhesive proteins and growth factors such as platelet-derived growth factor, transforming growth factor beta, vascular endothelial growth factor, basic fibroblast growth factor, Insulin-like growth factor-1 (IGF-1), and epidermal growth factor. All the healing elements in the body to travel through the blood, so using blood as a delivery vehicle makes sense.

Are you a candidate for our non-surgical treatments?

Ask Dr.Alleyne